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KMID : 1134819990280061321
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Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 6 p.1321 ~ p.1325
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Antimutagenic and Anticancer Effects of Ramaria botrytis(Fr.) Rick Extracts
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Kim Hyun-Jeong
Lee In-Seon
Lee Kap-Rang
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Abstract
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The inhibitory effect of Ramaria botrytis on the mutagenicity in Salmonella assay and cytotoxicity on cancer cell were studied. Ramaria botrytis methanol extracts showed antimutagenic effects of 60~90% on B(a)P and AFB₁ in S. typhimurium TA98 and TA100. These extracts showed 73~85% antimutagenicity on TA100 against MNNG. The ethanol extracts with strong antimutagenic activities were further fractionated by ethyl acetate and water, the ethyl acetate fraction were found to be stronger antimutagenicity against MNNG than water fraction. Ramaria botrytis methanol extracts and ethyl acetate fraction revealed the highest cytoxicity against HT-29 human colon adenocarcinoma cells in which cell growth was inhibited by 57~88% and 69~94% at 0.25~1.0㎎/ml, respectively. These methanol extract and ethylacetate fraction exhibited 53~79% and 66~87% inhibition against HepG2 human hepatocarcinoma cells, respectively. But water fraction showed only 10~24% inhibition. However, these extract and fractions did not show cytotoxic effect against human chang liver cells. From these results, it is considered that Ramaria botrytis has stronger antimutagenic and anticancer effects in vitro.
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KEYWORD
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Ramaria botrytis, antimutagenicity, anticancer effects
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